Products/Pipeline

Tamibarotene is a therapeutic agent for treating acute promyelocytic leukemia. Toko Pharmaceutical Industrial Co., Ltd. received approval for this agent in Japan in 2005. Acute promyelocytic leukemia develops when cancerous promyelocytes proliferate. This proliferation occurs when the differentiation of promyelocytes is inhibited by the PML-RARalpha chimeric gene, which is generated by the translocation of chromosome 15 with chromosome 17. Using Tamibarotene to target this stage, it is believed that the variant property of PML-RARalpha can be canceled and that the PML and RARalpha functions can be normalized, resulting in the differentiation induction of myeloid. Tamibarotene has also been reported to be effective in the treatment of acute promyelocytic leukemia patients who have stopped responding the Tretinoin.